Mix salt, pepper, onion powder, garlic powder, and paprika together in a small bowl. Rub this on all sides of the brisket.
Place brisket (fat side up) on top of the roasting rack in the pan. Add enough beef broth to cover the bottom of the pan by half an inch.
Cover tightly with aluminum foil (I use two pieces to make sure it's tight) or a lid and place in oven for 1 hour.
Reduce heat to 275F and cook an additional 3 hours (covered) or until fork tender. Check the liquid level at least once to make sure that it has not burned off if your oven runs hot. Add more broth if needed.
Cool ~ 15 minutes covered and slice thinly (trim any fat off the top if desired)
Serve with horseradish sour cream and/or sharp mustard on the side. You can also drizzle the brisket or soak the slices with the leftover pan sauce to keep it moist. Happy Eating! Beckie
Notes
If your oven runs way hot, the beef broth will evaporate. Check it half way through and add a little more beef broth if needed. You can always strain the fat off this after it's done cooking and use the sauce as a dipping Au Jus.
Make sure to let the beef brisket rest before slicing and then you can put the slices back in the sauces that it cooked in to ensure that it will stay moist and tender. It will soak it back up and is even better the next day.
Don't have all the spices? Just use salt and pepper and skip the rest.
Don't have beef broth? You can use chicken or vegetable broth, beer, or even water if you're in a pinch.